The latest opioid approved by FDA will be “expected” to reduce abuse by only one route — injection — in its official labeling.
In a carefully-worded press release, drugmaker Egalet said its extended-release morphine drug Arymo ER “increased resistance to cutting, crushing, grinding or breaking using a variety of tools. Due to its physical and chemical properties, Arymo ER is expected to make abuse by injection difficult.”
In an FDA advisory committee meeting last year, participants voted that the drug could deter abuse via the oral, nasal, and intravenous routes of abuse. But there were several reasons only the intravenous route won labeling.
An FDA spokesperson told MedPage Today that MorphaBond, another morphine product, has “marketing exclusivity for labeling describing the expected reduction of abuse of single-entity, extended-release morphine by the intranasal route due to physicochemical properties.” MORE HERE
Heroin, or diacetylmorphine to give it its scientific name, was first synthesized in 1874 by an English gentleman called C. R. Alder Wright. It wasn’t until 1898 that a man called Heinrich Dreser, head of drug development at German pharmaceutical company Bayer, saw the commercial potential in the drug.
Dreser started developing the drug as treatment for respiratory diseases such as bronchitis, asthma and tuberculosis, testing the drug on animals, human test subjects and even himself. Unsurprisingly Dreser and his test subjects liked the drug, saying it made them feel “heroisch” German for heroic. From this the brand name heroin was born.
Heroin was given a big thumbs up from Dreser and the Bayer big bosses. Samples of the drug were given out to doctors who in turn prescribed Heroin to their patients. Bayer was producing Heroin pastels, cough lozengers, tablets, water-soluble Heroin salts and a Heroin elixir.
Suspicion of the drug arose however when doctors started to report patients requesting Heroin cough syrup even though they weren’t showing any respiratory problems.
It turned out that Heroin was extremely addictive and detrimental to a person’s health. Bayer stopped producing and selling Heroin in 1913, deleting any mention of the drug in it’s company history. In 1924 Heroin was made illegal in the USA, even for medical purposes. In Britain, heroin is still used for medical purposes to this day, accounting for 95% of the worlds legal heroin use.