Tag Archives: Painkillers

Strong placebo response thwarts painkiller trials

Interesting article, placebo’s as effective as meds.

Drug companies have a problem: they are finding it ever harder to get painkillers through clinical trials. But this isn’t necessarily because the drugs are getting worse. An extensive analysis of trial data1 has found that responses to sham treatments have become stronger over time, making it harder to prove a drug’s advantage over placebo.

The change in response to placebo treatments for pain, discovered by researchers in Canada, holds true only for US clinical trials. “We were absolutely floored when we found out,” says Jeffrey Mogil, who directs the pain-genetics lab at McGill University in Montreal and led the analysis. Simply being in a US trial and receiving sham treatment now seems to relieve pain almost as effectively as many promising new drugs. Mogil thinks that as US trials get longer, larger and more expensive, they may be enhancing participants’ expectations of their effectiveness.

See the entire article here:  http://www.nature.com/news/strong-placebo-response-thwarts-painkiller-trials-1.18511?%3Fftcamp=crm%2Femail%2F%2Fnbe%2FFirstFTEurope%2Fproduct


N.H. Ranks High In Prescriptions For Addictive Painkillers

New Hampshire doctors are among the nation’s most prolific prescribers of Oxycontin and other opioids, according to a government report released Tuesday that analyzed the state-by-state use of highly addictive painkillers.1pillst

The study by the Centers for Disease Control ranked the Granite State third, behind Maine and Delaware, for per-capita prescriptions of Oxycontin, fentanyl and other long-acting opioids in 2012, even as the state ranked relatively low – 39th – for overall opioid prescribing. Read more HERE